Pre-Concentration Approaches Combined with Capillary Electrophoresis in Bioanalysis of Chiral Cardiovascular Drugs
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چکیده
منابع مشابه
Pre-Concentration Approaches Combined with Capillary Electrophoresis in Bioanalysis of Chiral Cardiovascular Drugs
Currently, there is a remarkable interest in the separation and quantification of enantiomeric compounds because of their importance in biochemistry, therapeutic drug monitoring (TDM), pharmaceutical, forensic, etc. In past decades the pharmacopoeia was governed by racemates, but nowadays the U.S. Food and Drug Administration (FDA) exclusively has been issued a statement that racemic new drugs ...
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Due to high resolution power of sulfated cyclodextrins (HS-CDs), utilization of these selectors for chiral resolution of 7 basic and 2 zwitterionic drugs have been examined. Experiments were performed on a HP3DCE instrument equipped with an on-column diode array UV absorbance detector. Fused silica capillaries with an inner diameter of 50 ?m, an outer diameter of 365 ?m, and a total length of 4...
متن کاملChiral Separation of Basic and Zwitterionic Drugs by Highly Sulfated Cyclodextrins Using Short-End Injection Capillary Electrophoresis Highly Sulfated Cyclodextrins Using Short-End Injection Capillary Electrophoresis
Due to high resolution power of sulfated cyclodextrins (HS-CDs), utilization of these selectors for chiral resolution of 7 basic and 2 zwitterionic drugs have been examined. Experiments were performed on a HP3DCE instrument equipped with an on-column diode array UV absorbance detector. Fused silica capillaries with an inner diameter of 50 ?m, an outer diameter of 365 ?m, and a total length of 4...
متن کاملChiral Separations in Capillary Electrophoresis
We carried out different research projects by using our expertise in the field of the study of equilibria in solution, the synthesis and the NMR characterisation of cyclodextrin derivatives, capillary electrophoresis techniques, and electrospray mass spectrometry for the detection and the characterisation of the involved analytes. The most of our work concerns the separation science, and partic...
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This review article addresses the developments and applications of capillary electromigration methods coupled on-line with mass spectrometry for chiral analysis. The multiple enantiomeric applications of this hyphenated technology are covered including chiral analysis of drugs, food compounds, pesticides, natural metabolites, etc., in different matrices such as plasma, urine, medicines, foods, ...
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ژورنال
عنوان ژورنال: Pharmaceutical Sciences
سال: 2015
ISSN: 2383-2886
DOI: 10.15171/ps.2015.42